Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polari...
Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay
About this item
Full title
Author / Creator
Hall, Justin , Brault, Amy , Vincent, Fabien , Weng, Shawn , Wang, Hong , Dumlao, Darren , Aulabaugh, Ann , Aivazian, Dikran , Castro, Dana , Chen, Ming , Culp, Jeffrey , Dower, Ken , Gardner, Joseph , Hawrylik, Steven , Golenbock, Douglas , Hepworth, David , Horn, Mark , Jones, Lyn , Jones, Peter , Latz, Eicke , Li, Jing , Lin, Lih-Ling , Lin, Wen , Lin, David , Lovering, Frank , Niljanskul, Nootaree , Nistler, Ryan , Pierce, Betsy , Plotnikova, Olga , Schmitt, Daniel , Shanker, Suman , Smith, James , Snyder, William , Subashi, Timothy , Trujillo, John , Tyminski, Edyta , Wang, Guoxing , Wong, Jimson , Lefker, Bruce , Dakin, Leslie , Leach, Karen and Argonne National Laboratory (ANL), Argonne, IL (United States)
Publisher
United States: Public Library of Science
Journal title
Language
English
Formats
Publication information
Publisher
United States: Public Library of Science
Subjects
More information
Scope and Contents
Contents
Cyclic GMP-AMP synthase (cGAS) initiates the innate immune system in response to cytosolic dsDNA. After binding and activation from dsDNA, cGAS uses ATP and GTP to synthesize 2', 3' -cGAMP (cGAMP), a cyclic dinucleotide second messenger with mixed 2'-5' and 3'-5' phosphodiester bonds. Inappropriate stimulation of cGAS has been implicated in autoimm...
Alternative Titles
Full title
Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay
Authors, Artists and Contributors
Author / Creator
Brault, Amy
Vincent, Fabien
Weng, Shawn
Wang, Hong
Dumlao, Darren
Aulabaugh, Ann
Aivazian, Dikran
Castro, Dana
Chen, Ming
Culp, Jeffrey
Dower, Ken
Gardner, Joseph
Hawrylik, Steven
Golenbock, Douglas
Hepworth, David
Horn, Mark
Jones, Lyn
Jones, Peter
Latz, Eicke
Li, Jing
Lin, Lih-Ling
Lin, Wen
Lin, David
Lovering, Frank
Niljanskul, Nootaree
Nistler, Ryan
Pierce, Betsy
Plotnikova, Olga
Schmitt, Daniel
Shanker, Suman
Smith, James
Snyder, William
Subashi, Timothy
Trujillo, John
Tyminski, Edyta
Wang, Guoxing
Wong, Jimson
Lefker, Bruce
Dakin, Leslie
Leach, Karen
Argonne National Laboratory (ANL), Argonne, IL (United States)
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_plos_journals_1941349602
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1941349602
Other Identifiers
ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0184843
