In vitro and in vivo effects of 2,4 diaminoquinazoline inhibitors of the decapping scavenger enzyme...
In vitro and in vivo effects of 2,4 diaminoquinazoline inhibitors of the decapping scavenger enzyme DcpS: Context-specific modulation of SMN transcript levels
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Full title
Author / Creator
Cherry, Jonathan J. , DiDonato, Christine J. , Androphy, Elliot J. , Calo, Alessandro , Potter, Kyle , Custer, Sara K. , Du, Sarah , Foley, Timothy L. , Gopalsamy, Ariamala , Reedich, Emily J. , Gordo, Susana M. , Gordon, William , Hosea, Natalie , Jones, Lyn H. , Krizay, Daniel K. , LaRosa, Gregory , Li, Hongxia , Mathur, Sachin , Menard, Carol A. , Patel, Paraj , Ramos-Zayas, Rebeca , Rietz, Anne , Rong, Haojing , Zhang, Baohong and Tones, Michael A.
Publisher
United States: Public Library of Science
Journal title
Language
English
Formats
Publication information
Publisher
United States: Public Library of Science
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More information
Scope and Contents
Contents
C5-substituted 2,4-diaminoquinazoline inhibitors of the decapping scavenger enzyme DcpS (DAQ-DcpSi) have been developed for the treatment of spinal muscular atrophy (SMA), which is caused by genetic deficiency in the Survival Motor Neuron (SMN) protein. These compounds are claimed to act as SMN2 transcriptional activators but data underlying that c...
Alternative Titles
Full title
In vitro and in vivo effects of 2,4 diaminoquinazoline inhibitors of the decapping scavenger enzyme DcpS: Context-specific modulation of SMN transcript levels
Authors, Artists and Contributors
Author / Creator
DiDonato, Christine J.
Androphy, Elliot J.
Calo, Alessandro
Potter, Kyle
Custer, Sara K.
Du, Sarah
Foley, Timothy L.
Gopalsamy, Ariamala
Reedich, Emily J.
Gordo, Susana M.
Gordon, William
Hosea, Natalie
Jones, Lyn H.
Krizay, Daniel K.
LaRosa, Gregory
Li, Hongxia
Mathur, Sachin
Menard, Carol A.
Patel, Paraj
Ramos-Zayas, Rebeca
Rietz, Anne
Rong, Haojing
Zhang, Baohong
Tones, Michael A.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_plos_journals_1942617731
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1942617731
Other Identifiers
ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0185079
