Fine Tuning of Globin Gene Expression by DNA Methylation
Fine Tuning of Globin Gene Expression by DNA Methylation
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United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
Expression patterns in the globin gene cluster are subject to developmental regulation in vivo. While the gamma(A) and gamma(G) genes are expressed in fetal liver, both are silenced in adult erythrocytes. In order to decipher the role of DNA methylation in this process, we generated a YAC transgenic mouse system that allowed us to control gamma(A)...
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Full title
Fine Tuning of Globin Gene Expression by DNA Methylation
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TN_cdi_plos_journals_1949664199
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1949664199
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0000046
