LPS responsiveness and neutrophil chemotaxis in vivo require PMN MMP-8 activity
LPS responsiveness and neutrophil chemotaxis in vivo require PMN MMP-8 activity
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United States: Public Library of Science
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English
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United States: Public Library of Science
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We identify matrix metalloproteinase (MMP)-8, the polymorphonuclear (PMN) leukocyte collagenase, as a critical mediator initiating lipopolysaccharide (LPS)-responsiveness in vivo. PMN infiltration towards LPS is abrogated in Mmp8-null mice. MMP-8 cleaves LPS-induced CXC chemokine (LIX) at Ser(4)-Val(5) and Lys(79)-Arg(80). LIX bioactivity is increa...
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Full title
LPS responsiveness and neutrophil chemotaxis in vivo require PMN MMP-8 activity
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TN_cdi_plos_journals_1950101713
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1950101713
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0000312
