Interphase Nucleo-Cytoplasmic Shuttling and Localization of SIRT2 during Mitosis
Interphase Nucleo-Cytoplasmic Shuttling and Localization of SIRT2 during Mitosis
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
The human NAD+-dependent protein deacetylase SIRT2 resides predominantly in the cytoplasm where it functions as a tubulin deacetylase. Here we report that SIRT2 maintains a largely cytoplasmic localization during interphase by active nuclear export in a Crm1-dependent manner. We identified a functional, leptomycin B-sensitive, nuclear export signal...
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Full title
Interphase Nucleo-Cytoplasmic Shuttling and Localization of SIRT2 during Mitosis
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TN_cdi_plos_journals_1950156457
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1950156457
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0000784
