Negative Selection on BRCA1 Susceptibility Alleles Sheds Light on the Population Genetics of Late-On...
Negative Selection on BRCA1 Susceptibility Alleles Sheds Light on the Population Genetics of Late-Onset Diseases and Aging Theory
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United States: Public Library of Science
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English
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United States: Public Library of Science
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The magnitude of negative selection on alleles involved in age-specific mortality decreases with age. This is the foundation of the evolutionary theory of senescence. Because of this decrease in negative selection with age, and because of the absence of reproduction after menopause, alleles involved in women's late-onset diseases are generally cons...
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Negative Selection on BRCA1 Susceptibility Alleles Sheds Light on the Population Genetics of Late-Onset Diseases and Aging Theory
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TN_cdi_plos_journals_1950341960
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1950341960
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0001206
