HBV core protein allosteric modulators differentially alter cccDNA biosynthesis from de novo infecti...
HBV core protein allosteric modulators differentially alter cccDNA biosynthesis from de novo infection and intracellular amplification pathways
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Author / Creator
Guo, Fang , Zhao, Qiong , Sheraz, Muhammad , Cheng, Junjun , Qi, Yonghe , Su, Qing , Cuconati, Andrea , Wei, Lai , Du, Yanming , Li, Wenhui , Chang, Jinhong and Guo, Ju-Tao
Publisher
United States: Public Library of Science
Journal title
Language
English
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Publisher
United States: Public Library of Science
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Contents
Hepatitis B virus (HBV) core protein assembles viral pre-genomic (pg) RNA and DNA polymerase into nucleocapsids for reverse transcriptional DNA replication to take place. Several chemotypes of small molecules, including heteroaryldihydropyrimidines (HAPs) and sulfamoylbenzamides (SBAs), have been discovered to allosterically modulate core protein s...
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Full title
HBV core protein allosteric modulators differentially alter cccDNA biosynthesis from de novo infection and intracellular amplification pathways
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TN_cdi_plos_journals_1951453401
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1951453401
Other Identifiers
ISSN
1553-7374,1553-7366
E-ISSN
1553-7374
DOI
10.1371/journal.ppat.1006658
