Tubastatin ameliorates pulmonary fibrosis by targeting the TGFβ-PI3K-Akt pathway
Tubastatin ameliorates pulmonary fibrosis by targeting the TGFβ-PI3K-Akt pathway
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United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive and fatal disease. Histone deacetylase 6 (HDAC6) alters function and fate of various proteins via deacetylation of lysine residues, and is implicated in TGF-β1-induced EMT (epithelial-mesenchymal transition). However, the role of HDAC6 in pulmonary fibrosis is unknown.
HDAC6 expressio...
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Full title
Tubastatin ameliorates pulmonary fibrosis by targeting the TGFβ-PI3K-Akt pathway
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TN_cdi_plos_journals_1952654554
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1952654554
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0186615
