miRNA independent hepacivirus variants suggest a strong evolutionary pressure to maintain miR-122 de...
miRNA independent hepacivirus variants suggest a strong evolutionary pressure to maintain miR-122 dependence
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United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
Hepatitis C virus (HCV) requires the liver specific micro-RNA (miRNA), miR-122, to replicate. This was considered unique among RNA viruses until recent discoveries of HCV-related hepaciviruses prompting the question of a more general miR-122 dependence. Among hepaciviruses, the closest known HCV relative is the equine non-primate hepacivirus (NPHV)...
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Full title
miRNA independent hepacivirus variants suggest a strong evolutionary pressure to maintain miR-122 dependence
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TN_cdi_plos_journals_1965107466
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1965107466
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ISSN
1553-7374,1553-7366
E-ISSN
1553-7374
DOI
10.1371/journal.ppat.1006694
