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Inhibition of the H3K9 methyltransferase G9A attenuates oncogenicity and activates the hypoxia signa...

Inhibition of the H3K9 methyltransferase G9A attenuates oncogenicity and activates the hypoxia signa...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1965167166

Inhibition of the H3K9 methyltransferase G9A attenuates oncogenicity and activates the hypoxia signaling pathway

About this item

Full title

Inhibition of the H3K9 methyltransferase G9A attenuates oncogenicity and activates the hypoxia signaling pathway

Publisher

United States: Public Library of Science

Journal title

PloS one, 2017-11, Vol.12 (11), p.e0188051-e0188051

Language

English

Formats

Publication information

Publisher

United States: Public Library of Science

More information

Scope and Contents

Contents

Epigenetic mechanisms play important roles in the regulation of tumorigenesis, and hypoxia-induced epigenetic changes may be critical for the adaptation of cancer cells to the hypoxic microenvironment of solid tumors. Previously, we showed that loss-of-function of the hypoxia-regulated H3K9 methyltransferase G9A attenuates tumor growth. However, th...

Alternative Titles

Full title

Inhibition of the H3K9 methyltransferase G9A attenuates oncogenicity and activates the hypoxia signaling pathway

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_plos_journals_1965167166

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1965167166

Other Identifiers

ISSN

1932-6203

E-ISSN

1932-6203

DOI

10.1371/journal.pone.0188051

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