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Human hepatic lipase overexpression in mice induces hepatic steatosis and obesity through promoting...

Human hepatic lipase overexpression in mice induces hepatic steatosis and obesity through promoting...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1977543264

Human hepatic lipase overexpression in mice induces hepatic steatosis and obesity through promoting hepatic lipogenesis and white adipose tissue lipolysis and fatty acid uptake

About this item

Full title

Human hepatic lipase overexpression in mice induces hepatic steatosis and obesity through promoting hepatic lipogenesis and white adipose tissue lipolysis and fatty acid uptake

Publisher

United States: Public Library of Science

Journal title

PloS one, 2017-12, Vol.12 (12), p.e0189834-e0189834

Language

English

Formats

Publication information

Publisher

United States: Public Library of Science

More information

Scope and Contents

Contents

Human hepatic lipase (hHL) is mainly localized on the hepatocyte cell surface where it hydrolyzes lipids from remnant lipoproteins and high density lipoproteins and promotes their hepatic selective uptake. Furthermore, hepatic lipase (HL) is closely associated with obesity in multiple studies. Therefore, HL may play a key role on lipid homeostasis...

Alternative Titles

Full title

Human hepatic lipase overexpression in mice induces hepatic steatosis and obesity through promoting hepatic lipogenesis and white adipose tissue lipolysis and fatty acid uptake

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_plos_journals_1977543264

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1977543264

Other Identifiers

ISSN

1932-6203

E-ISSN

1932-6203

DOI

10.1371/journal.pone.0189834

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