Reversible dual inhibitor against G9a and DNMT1 improves human iPSC derivation enhancing MET and fac...
Reversible dual inhibitor against G9a and DNMT1 improves human iPSC derivation enhancing MET and facilitating transcription factor engagement to the genome
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United States: Public Library of Science
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English
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United States: Public Library of Science
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The combination of defined factors with small molecules targeting epigenetic factors is a strategy that has been shown to enhance optimal derivation of iPSCs and could be used for disease modelling, high throughput screenings and/or regenerative medicine applications. In this study, we showed that a new first-in-class reversible dual G9a/DNMT1 inhi...
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Reversible dual inhibitor against G9a and DNMT1 improves human iPSC derivation enhancing MET and facilitating transcription factor engagement to the genome
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TN_cdi_plos_journals_1981046222
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1981046222
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1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0190275
