Impaired PGE2-stimulated Cl- and HCO3- secretion contributes to cystic fibrosis airway disease
Impaired PGE2-stimulated Cl- and HCO3- secretion contributes to cystic fibrosis airway disease
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United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Scope and Contents
Contents
Airway mucociliary clearance (MCC) is an important defense mechanism against pulmonary infections and is compromised in cystic fibrosis (CF). Cl- and HCO3- epithelial transport are integral to MCC. During pulmonary infections prostaglandin E2 (PGE2) production is abundant.
To determine the effect of PGE2 on airway Cl- and HCO3- secretion and MCC...
Alternative Titles
Full title
Impaired PGE2-stimulated Cl- and HCO3- secretion contributes to cystic fibrosis airway disease
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TN_cdi_plos_journals_1981046228
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1981046228
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0189894
