Safety, pharmacokinetics, and immunological activities of multiple intravenous or subcutaneous doses...
Safety, pharmacokinetics, and immunological activities of multiple intravenous or subcutaneous doses of an anti-HIV monoclonal antibody, VRC01, administered to HIV-uninfected adults: Results of a phase 1 randomized trial
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Full title
Author / Creator
Mayer, Kenneth H. , Seaton, Kelly E. , Huang, Yunda , Grunenberg, Nicole , Isaacs, Abby , Allen, Mary , Ledgerwood, Julie E. , Frank, Ian , Sobieszczyk, Magdalena E. , Baden, Lindsey R. , Rodriguez, Benigno , Van Tieu, Hong , Tomaras, Georgia D. , Deal, Aaron , Goodman, Derrick , Bailer, Robert T. , Ferrari, Guido , Jensen, Ryan , Hural, John , Graham, Barney S. , Mascola, John R. , Corey, Lawrence , Montefiori, David C. , on behalf of the HVTN 104 Protocol Team , and the NIAID HIV Vaccine Trials Network and HVTN 104 Protocol Team
Publisher
United States: Public Library of Science
Journal title
Language
English
Formats
Publication information
Publisher
United States: Public Library of Science
Subjects
More information
Scope and Contents
Contents
VRC01 is an HIV-1 CD4 binding site broadly neutralizing antibody (bnAb) that is active against a broad range of HIV-1 primary isolates in vitro and protects against simian-human immunodeficiency virus (SHIV) when delivered parenterally to nonhuman primates. It has been shown to be safe and well tolerated after short-term administration in humans; h...
Alternative Titles
Full title
Safety, pharmacokinetics, and immunological activities of multiple intravenous or subcutaneous doses of an anti-HIV monoclonal antibody, VRC01, administered to HIV-uninfected adults: Results of a phase 1 randomized trial
Authors, Artists and Contributors
Author / Creator
Seaton, Kelly E.
Huang, Yunda
Grunenberg, Nicole
Isaacs, Abby
Allen, Mary
Ledgerwood, Julie E.
Frank, Ian
Sobieszczyk, Magdalena E.
Baden, Lindsey R.
Rodriguez, Benigno
Van Tieu, Hong
Tomaras, Georgia D.
Deal, Aaron
Goodman, Derrick
Bailer, Robert T.
Ferrari, Guido
Jensen, Ryan
Hural, John
Graham, Barney S.
Mascola, John R.
Corey, Lawrence
Montefiori, David C.
on behalf of the HVTN 104 Protocol Team
and the NIAID HIV Vaccine Trials Network
HVTN 104 Protocol Team
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_plos_journals_1989018251
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1989018251
Other Identifiers
ISSN
1549-1676,1549-1277
E-ISSN
1549-1676
DOI
10.1371/journal.pmed.1002435
