Combined lipidomic and proteomic analysis of isolated human islets exposed to palmitate reveals time...
Combined lipidomic and proteomic analysis of isolated human islets exposed to palmitate reveals time-dependent changes in insulin secretion and lipid metabolism
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United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
Studies on the pathophysiology of type 2 diabetes mellitus (T2DM) have linked the accumulation of lipid metabolites to the development of beta-cell dysfunction and impaired insulin secretion. In most in vitro models of T2DM, rodent islets or beta-cell lines are used and typically focus is on specific cellular pathways or organs. Our aim was to, fir...
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Full title
Combined lipidomic and proteomic analysis of isolated human islets exposed to palmitate reveals time-dependent changes in insulin secretion and lipid metabolism
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TN_cdi_plos_journals_1989977312
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1989977312
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0176391
