Combined MEK and ERK inhibition overcomes therapy-mediated pathway reactivation in RAS mutant tumors
Combined MEK and ERK inhibition overcomes therapy-mediated pathway reactivation in RAS mutant tumors
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Author / Creator
Merchant, Mark , Moffat, John , Schaefer, Gabriele , Chan, Jocelyn , Wang, Xi , Orr, Christine , Cheng, Jason , Hunsaker, Thomas , Shao, Lily , Wang, Stephanie J , Wagle, Marie-Claire , Lin, Eva , Haverty, Peter M , Shahidi-Latham, Sheerin , Ngu, Hai , Solon, Margaret , Eastham-Anderson, Jeffrey , Koeppen, Hartmut , Huang, Shih-Min A , Schwarz, Jacob , Belvin, Marcia , Kirouac, Daniel and Junttila, Melissa R
Publisher
United States: Public Library of Science
Journal title
Language
English
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Publication information
Publisher
United States: Public Library of Science
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Scope and Contents
Contents
Mitogen-activated protein kinase (MAPK) pathway dysregulation is implicated in >30% of all cancers, rationalizing the development of RAF, MEK and ERK inhibitors. While BRAF and MEK inhibitors improve BRAF mutant melanoma patient outcomes, these inhibitors had limited success in other MAPK dysregulated tumors, with insufficient pathway suppression a...
Alternative Titles
Full title
Combined MEK and ERK inhibition overcomes therapy-mediated pathway reactivation in RAS mutant tumors
Authors, Artists and Contributors
Author / Creator
Moffat, John
Schaefer, Gabriele
Chan, Jocelyn
Wang, Xi
Orr, Christine
Cheng, Jason
Hunsaker, Thomas
Shao, Lily
Wang, Stephanie J
Wagle, Marie-Claire
Lin, Eva
Haverty, Peter M
Shahidi-Latham, Sheerin
Ngu, Hai
Solon, Margaret
Eastham-Anderson, Jeffrey
Koeppen, Hartmut
Huang, Shih-Min A
Schwarz, Jacob
Belvin, Marcia
Kirouac, Daniel
Junttila, Melissa R
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_plos_journals_1991851104
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1991851104
Other Identifiers
ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0185862
