Fab-based inhibitors reveal ubiquitin independent functions for HIV Vif neutralization of APOBEC3 re...
Fab-based inhibitors reveal ubiquitin independent functions for HIV Vif neutralization of APOBEC3 restriction factors
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Author / Creator
Binning, Jennifer M , Smith, Amber M , Hultquist, Judd F , Craik, Charles S , Caretta Cartozo, Nathalie , Campbell, Melody G , Burton, Lily , La Greca, Florencia , McGregor, Michael J , Ta, Hai M , Bartholomeeusen, Koen , Peterlin, B Matija , Krogan, Nevan J , Sevillano, Natalia , Cheng, Yifan and Gross, John D
Publisher
United States: Public Library of Science
Journal title
Language
English
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Publisher
United States: Public Library of Science
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Contents
The lentiviral protein Viral Infectivity Factor (Vif) counteracts the antiviral effects of host APOBEC3 (A3) proteins and contributes to persistent HIV infection. Vif targets A3 restriction factors for ubiquitination and proteasomal degradation by recruiting them to a multi-protein ubiquitin E3 ligase complex. Here, we describe a degradation-indepe...
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Full title
Fab-based inhibitors reveal ubiquitin independent functions for HIV Vif neutralization of APOBEC3 restriction factors
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TN_cdi_plos_journals_2002619272
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2002619272
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ISSN
1553-7374,1553-7366
E-ISSN
1553-7374
DOI
10.1371/journal.ppat.1006830
