A model for cooperative gating of L-type Ca2+ channels and its effects on cardiac alternans dynamics
A model for cooperative gating of L-type Ca2+ channels and its effects on cardiac alternans dynamics
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United States: Public Library of Science
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English
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United States: Public Library of Science
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Contents
In ventricular myocytes, membrane depolarization during the action potential (AP) causes synchronous activation of multiple L-type CaV1.2 channels (LTCCs), which trigger the release of calcium (Ca2+) from the sarcoplasmic reticulum (SR). This results in an increase in intracellular Ca2+ (Cai) that initiates contraction. During pulsus alternans, car...
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Full title
A model for cooperative gating of L-type Ca2+ channels and its effects on cardiac alternans dynamics
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TN_cdi_plos_journals_2002622732
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2002622732
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ISSN
1553-7358,1553-734X
E-ISSN
1553-7358
DOI
10.1371/journal.pcbi.1005906
