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Expansion of human and murine hematopoietic stem and progenitor cells ex vivo without genetic modifi...

Expansion of human and murine hematopoietic stem and progenitor cells ex vivo without genetic modifi...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2014436207

Expansion of human and murine hematopoietic stem and progenitor cells ex vivo without genetic modification using MYC and Bcl-2 fusion proteins

About this item

Full title

Expansion of human and murine hematopoietic stem and progenitor cells ex vivo without genetic modification using MYC and Bcl-2 fusion proteins

Publisher

United States: Public Library of Science

Journal title

PloS one, 2014-08, Vol.9 (8), p.e105525-e105525

Language

English

Formats

Publication information

Publisher

United States: Public Library of Science

More information

Scope and Contents

Contents

The long-term repopulating hematopoietic stem cell (HSC) population can self-renew in vivo, support hematopoiesis for the lifetime of the individual, and is of critical importance in the context of bone marrow stem cell transplantation. The mechanisms that regulate the expansion of HSCs in vivo and in vitro remain unclear to date. Since the current...

Alternative Titles

Full title

Expansion of human and murine hematopoietic stem and progenitor cells ex vivo without genetic modification using MYC and Bcl-2 fusion proteins

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_plos_journals_2014436207

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2014436207

Other Identifiers

ISSN

1932-6203

E-ISSN

1932-6203

DOI

10.1371/journal.pone.0105525

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