Homozygous KSR1 deletion attenuates morbidity but does not prevent tumor development in a mouse mode...
Homozygous KSR1 deletion attenuates morbidity but does not prevent tumor development in a mouse model of RAS-driven pancreatic cancer
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United States: Public Library of Science
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English
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United States: Public Library of Science
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Given the frequency with which MAP kinase signaling is dysregulated in cancer, much effort has been focused on inhibiting RAS signaling for therapeutic benefit. KSR1, a pseudokinase that interacts with RAF, is a potential target; it was originally cloned in screens for suppressors of constitutively active RAS, and its deletion prevents RAS-mediated...
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Homozygous KSR1 deletion attenuates morbidity but does not prevent tumor development in a mouse model of RAS-driven pancreatic cancer
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TN_cdi_plos_journals_2019802725
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2019802725
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0194998
