PTEN suppresses axon outgrowth by down-regulating the level of detyrosinated microtubules
PTEN suppresses axon outgrowth by down-regulating the level of detyrosinated microtubules
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Publisher
United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
Inhibition of the phospholipid phosphatase and tumor suppressor PTEN leads to excessive polarized cell growth during directed cell migration and neurite outgrowth. These processes require the precise regulation of both the actin and microtubule cytoskeleton. While PTEN is known to regulate actin dynamics through phospholipid modulation, whether and...
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Full title
PTEN suppresses axon outgrowth by down-regulating the level of detyrosinated microtubules
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TN_cdi_plos_journals_2021717242
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2021717242
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0193257
