Autophagic flux blockage by accumulation of weakly basic tenovins leads to elimination of B-Raf muta...
Autophagic flux blockage by accumulation of weakly basic tenovins leads to elimination of B-Raf mutant tumour cells that survive vemurafenib
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Author / Creator
Ladds, Marcus J. G. W. , Pastor-Fernández, Andrés , Popova, Gergana , van Leeuwen, Ingeborg M. M. , Eng, Kai Er , Drummond, Catherine J. , Johansson, Lars , Svensson, Richard , Westwood, Nicholas J. , McCarthy, Anna R. , Tholander, Fredrik , Popa, Mihaela , Lane, David P. , McCormack, Emmet , McInerney, Gerald M. , Bhatia, Ravi and Laín, Sonia
Publisher
United States: Public Library of Science
Journal title
Language
English
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Publisher
United States: Public Library of Science
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Contents
Tenovin-6 is the most studied member of a family of small molecules with antitumour activity in vivo. Previously, it has been determined that part of the effects of tenovin-6 associate with its ability to inhibit SirT1 and activate p53. However, tenovin-6 has also been shown to modulate autophagic flux. Here we show that blockage of autophagic flux...
Alternative Titles
Full title
Autophagic flux blockage by accumulation of weakly basic tenovins leads to elimination of B-Raf mutant tumour cells that survive vemurafenib
Authors, Artists and Contributors
Author / Creator
Pastor-Fernández, Andrés
Popova, Gergana
van Leeuwen, Ingeborg M. M.
Eng, Kai Er
Drummond, Catherine J.
Johansson, Lars
Svensson, Richard
Westwood, Nicholas J.
McCarthy, Anna R.
Tholander, Fredrik
Popa, Mihaela
Lane, David P.
McCormack, Emmet
McInerney, Gerald M.
Bhatia, Ravi
Laín, Sonia
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Primary Identifiers
Record Identifier
TN_cdi_plos_journals_2029591636
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2029591636
Other Identifiers
ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0195956
