The KAT5-Acetyl-Histone4-Brd4 axis silences HIV-1 transcription and promotes viral latency
The KAT5-Acetyl-Histone4-Brd4 axis silences HIV-1 transcription and promotes viral latency
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Publisher
United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
The bromodomain protein Brd4 promotes HIV-1 latency by competitively inhibiting P-TEFb-mediated transcription induced by the virus-encoded Tat protein. Brd4 is recruited to the HIV LTR by interactions with acetyl-histones3 (AcH3) and AcH4. However, the precise modification pattern that it reads and the writer for generating this pattern are unknown...
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Full title
The KAT5-Acetyl-Histone4-Brd4 axis silences HIV-1 transcription and promotes viral latency
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TN_cdi_plos_journals_2039772031
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2039772031
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ISSN
1553-7374,1553-7366
E-ISSN
1553-7374
DOI
10.1371/journal.ppat.1007012
