Role of duplicate genes in determining the tissue-selectivity of hereditary diseases
Role of duplicate genes in determining the tissue-selectivity of hereditary diseases
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Publisher
United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Scope and Contents
Contents
A longstanding puzzle in human genetics is what limits the clinical manifestation of hundreds of hereditary diseases to certain tissues, while their causal genes are expressed throughout the human body. A general conception is that tissue-selective disease phenotypes emerge when masking factors operate in unaffected tissues, but are specifically ab...
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Full title
Role of duplicate genes in determining the tissue-selectivity of hereditary diseases
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TN_cdi_plos_journals_2049971107
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2049971107
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ISSN
1553-7404,1553-7390
E-ISSN
1553-7404
DOI
10.1371/journal.pgen.1007327
