Loss of murine Gfi1 causes neutropenia and induces osteoporosis depending on the pathogen load and s...
Loss of murine Gfi1 causes neutropenia and induces osteoporosis depending on the pathogen load and systemic inflammation
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Gfi1 is a key molecule in hematopoietic lineage development and mutations in GFI1 cause severe congenital neutropenia (SCN). Neutropenia is associated with low bone mass, but the underlying mechanisms are poorly characterized. Using Gfi1 knock-out mice (Gfi1-ko/ko) as SCN model, we studied the relationship between neutropenia and bone mass upon dif...
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Full title
Loss of murine Gfi1 causes neutropenia and induces osteoporosis depending on the pathogen load and systemic inflammation
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TN_cdi_plos_journals_2051644008
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2051644008
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0198510
