Non-canonical role of the SNARE protein Ykt6 in autophagosome-lysosome fusion
Non-canonical role of the SNARE protein Ykt6 in autophagosome-lysosome fusion
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United States: Public Library of Science
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English
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United States: Public Library of Science
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The autophagosomal SNARE Syntaxin17 (Syx17) forms a complex with Snap29 and Vamp7/8 to promote autophagosome-lysosome fusion via multiple interactions with the tethering complex HOPS. Here we demonstrate that, unexpectedly, one more SNARE (Ykt6) is also required for autophagosome clearance in Drosophila. We find that loss of Ykt6 leads to large-sca...
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Full title
Non-canonical role of the SNARE protein Ykt6 in autophagosome-lysosome fusion
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TN_cdi_plos_journals_2056434216
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2056434216
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ISSN
1553-7404,1553-7390
E-ISSN
1553-7404
DOI
10.1371/journal.pgen.1007359
