Activation of Th2 cells downregulates CRTh2 through an NFAT1 mediated mechanism
Activation of Th2 cells downregulates CRTh2 through an NFAT1 mediated mechanism
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United States: Public Library of Science
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English
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United States: Public Library of Science
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CRTh2 (encoded by PTGDR2) is a G-protein coupled receptor expressed by Th2 cells as well as eosinophils, basophils and innate lymphoid cells (ILC)2s. Activation of CRTh2, by its ligand prostaglandin (PG)D2, mediates production of type 2 cytokines (IL-4, IL-5 and IL-13), chemotaxis and inhibition of apoptosis. As such, the PGD2-CRTh2 pathway is cons...
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Full title
Activation of Th2 cells downregulates CRTh2 through an NFAT1 mediated mechanism
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TN_cdi_plos_journals_2063686218
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2063686218
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0199156
