A speed–fidelity trade-off determines the mutation rate and virulence of an RNA virus
A speed–fidelity trade-off determines the mutation rate and virulence of an RNA virus
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Mutation rates can evolve through genetic drift, indirect selection due to genetic hitchhiking, or direct selection on the physicochemical cost of high fidelity. However, for many systems, it has been difficult to disentangle the relative impact of these forces empirically. In RNA viruses, an observed correlation between mutation rate and virulence...
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A speed–fidelity trade-off determines the mutation rate and virulence of an RNA virus
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TN_cdi_plos_journals_2070854294
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2070854294
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ISSN
1545-7885,1544-9173
E-ISSN
1545-7885
DOI
10.1371/journal.pbio.2006459
