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The mRNA cap methyltransferase gene TbCMT1 is not essential in vitro but is a virulence factor in vi...

The mRNA cap methyltransferase gene TbCMT1 is not essential in vitro but is a virulence factor in vi...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2075521264

The mRNA cap methyltransferase gene TbCMT1 is not essential in vitro but is a virulence factor in vivo for bloodstream form Trypanosoma brucei

About this item

Full title

The mRNA cap methyltransferase gene TbCMT1 is not essential in vitro but is a virulence factor in vivo for bloodstream form Trypanosoma brucei

Publisher

United States: Public Library of Science

Journal title

PloS one, 2018-07, Vol.13 (7), p.e0201263

Language

English

Formats

Publication information

Publisher

United States: Public Library of Science

More information

Scope and Contents

Contents

Messenger RNA is modified by the addition of a 5' methylated cap structure, which protects the transcript and recruits protein complexes that mediate RNA processing and/or the initiation of translation. Two genes encoding mRNA cap methyltransferases have been identified in T. brucei: TbCMT1 and TbCGM1. Here we analysed the impact of TbCMT1 gene del...

Alternative Titles

Full title

The mRNA cap methyltransferase gene TbCMT1 is not essential in vitro but is a virulence factor in vivo for bloodstream form Trypanosoma brucei

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_plos_journals_2075521264

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2075521264

Other Identifiers

ISSN

1932-6203

E-ISSN

1932-6203

DOI

10.1371/journal.pone.0201263

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