Deubiquitinase inhibitor PR-619 reduces Smad4 expression and suppresses renal fibrosis in mice with...
Deubiquitinase inhibitor PR-619 reduces Smad4 expression and suppresses renal fibrosis in mice with unilateral ureteral obstruction
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United States: Public Library of Science
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English
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United States: Public Library of Science
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Deubiquitinating enzymes (DUBs) remove ubiquitin from their substrates and, together with ubiquitin ligases, play an important role in the regulation of protein expression. Although transforming growth factor (TGF)-β1-Smad signaling is a central pathway of renal fibrosis, the role of DUBs in the expression of TGF-β receptors and Smads during the de...
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Deubiquitinase inhibitor PR-619 reduces Smad4 expression and suppresses renal fibrosis in mice with unilateral ureteral obstruction
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TN_cdi_plos_journals_2089280041
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2089280041
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0202409
