Phase I study of onapristone, a type I antiprogestin, in female patients with previously treated rec...
Phase I study of onapristone, a type I antiprogestin, in female patients with previously treated recurrent or metastatic progesterone receptor-expressing cancers
About this item
Full title
Author / Creator
Cottu, Paul H. , Bonneterre, Jacques , Varga, Andrea , Campone, Mario , Leary, Alexandra , Floquet, Anne , Berton-Rigaud, Dominique , Sablin, Marie-Paule , Lesoin, Anne , Rezai, Keyvan , Lokiec, François M. , Lhomme, Catherine , Bosq, Jacques , Bexon, Alice S. , Gilles, Erard M. , Proniuk, Stefan , Dieras, Veronique , Jackson, David M. , Zukiwski, Alexander and Italiano, Antoine
Publisher
United States: Public Library of Science
Journal title
Language
English
Formats
Publication information
Publisher
United States: Public Library of Science
Subjects
More information
Scope and Contents
Contents
Onapristone is a type I progesterone receptor (PR) antagonist, which prevents PR- mediated DNA transcription. Onapristone is active in multiple preclinical models and two prior studies demonstrated promising activity in patients with breast cancer. We conducted a study of extended release (ER) Onapristone to determine a recommended dose and explore...
Alternative Titles
Full title
Phase I study of onapristone, a type I antiprogestin, in female patients with previously treated recurrent or metastatic progesterone receptor-expressing cancers
Authors, Artists and Contributors
Author / Creator
Bonneterre, Jacques
Varga, Andrea
Campone, Mario
Leary, Alexandra
Floquet, Anne
Berton-Rigaud, Dominique
Sablin, Marie-Paule
Lesoin, Anne
Rezai, Keyvan
Lokiec, François M.
Lhomme, Catherine
Bosq, Jacques
Bexon, Alice S.
Gilles, Erard M.
Proniuk, Stefan
Dieras, Veronique
Jackson, David M.
Zukiwski, Alexander
Italiano, Antoine
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_plos_journals_2118222831
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2118222831
Other Identifiers
ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0204973
