GPR108, an NF-κB activator suppressed by TIRAP, negatively regulates TLR-triggered immune responses
GPR108, an NF-κB activator suppressed by TIRAP, negatively regulates TLR-triggered immune responses
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United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
Higher vertebrates have evolved innate and adaptive immune systems to defend against foreign substances and pathogens. Sophisticated regulatory circuits are needed to avoid inappropriate immune responses and inflammation. GPR108 is a seven-transmembrane family protein that activates NF-κB strongly when overexpressed. Surprisingly, its action in a p...
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Full title
GPR108, an NF-κB activator suppressed by TIRAP, negatively regulates TLR-triggered immune responses
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TN_cdi_plos_journals_2121470029
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2121470029
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0205303
