Use of a sequential high throughput screening assay to identify novel inhibitors of the eukaryotic S...
Use of a sequential high throughput screening assay to identify novel inhibitors of the eukaryotic SRP-Sec61 targeting/translocation pathway
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United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
The SRP-Sec61 targeting/translocation pathway of eukaryotic cells targets nascent protein chains to the membrane of the endoplasmic reticulum. Using this machinery, secretory proteins are translocated across this membrane whereas membrane proteins are integrated into the lipid bilayer. One of the key players of the pathway is the protein-conducting...
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Use of a sequential high throughput screening assay to identify novel inhibitors of the eukaryotic SRP-Sec61 targeting/translocation pathway
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TN_cdi_plos_journals_2155908095
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2155908095
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0208641
