Protein engineering strategies for improving the selective methylation of target CpG sites by a dCas...
Protein engineering strategies for improving the selective methylation of target CpG sites by a dCas9-directed cytosine methyltransferase in bacteria
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Mammalian gene expression is a complex process regulated in part by CpG methylation. The ability to target methylation for de novo gene regulation could have therapeutic and research applications. We have previously developed a dCas9-MC/MN protein for targeting CpG methylation. dCas9-MC/MN is composed of an artificially split M.SssI methyltransfera...
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Full title
Protein engineering strategies for improving the selective methylation of target CpG sites by a dCas9-directed cytosine methyltransferase in bacteria
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TN_cdi_plos_journals_2158234644
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2158234644
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0209408
