Prg4 prevents osteoarthritis induced by dominant-negative interference of TGF-β signaling in mice
Prg4 prevents osteoarthritis induced by dominant-negative interference of TGF-β signaling in mice
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San Francisco: Public Library of Science
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English
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San Francisco: Public Library of Science
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Objective Prg4, also known as Lubricin, acts as a joint/boundary lubricant. Prg4 has been used to prevent surgically induced osteoarthritis (OA) in mice. Surgically induced OA serves as a good model for post-traumatic OA but is not ideal for recapitulating age-related OA. Reduced expression of the TGF-β type II receptor (TGFβR2) is associated with...
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Prg4 prevents osteoarthritis induced by dominant-negative interference of TGF-β signaling in mice
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TN_cdi_plos_journals_2166102167
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2166102167
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E-ISSN
1932-6203
DOI
10.1371/journal.pone.0210601
