An analog of glibenclamide selectively enhances autophagic degradation of misfolded α1-antitrypsin Z
An analog of glibenclamide selectively enhances autophagic degradation of misfolded α1-antitrypsin Z
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United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
The classical form of α1-antitrypsin deficiency (ATD) is characterized by intracellular accumulation of the misfolded variant α1-antitrypsin Z (ATZ) and severe liver disease in some of the affected individuals. In this study, we investigated the possibility of discovering novel therapeutic agents that would reduce ATZ accumulation by interrogating...
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Full title
An analog of glibenclamide selectively enhances autophagic degradation of misfolded α1-antitrypsin Z
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TN_cdi_plos_journals_2170382780
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2170382780
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0209748
