The mouse KLF1 Nan variant impairs nuclear condensation and erythroid maturation
The mouse KLF1 Nan variant impairs nuclear condensation and erythroid maturation
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Krüppel-like factor 1 (KLF1) is an essential transcription factor for erythroid development, as demonstrated by Klf1 knockout mice which die around E14 due to severe anemia. In humans, >140 KLF1 variants, causing different erythroid phenotypes, have been described. The KLF1 Nan variant, a single amino acid substitution (p.E339D) in the DNA binding...
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Full title
The mouse KLF1 Nan variant impairs nuclear condensation and erythroid maturation
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TN_cdi_plos_journals_2200224314
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2200224314
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0208659
