Identification of druggable small molecule antagonists of the Plasmodium falciparum hexose transport...
Identification of druggable small molecule antagonists of the Plasmodium falciparum hexose transporter PfHT and assessment of ligand access to the glucose permeation pathway via FLAG-mediated protein engineering
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
Although the Plasmodium falciparum hexose transporter PfHT has emerged as a promising target for anti-malarial therapy, previously identified small-molecule inhibitors have lacked promising drug-like structural features necessary for development as clinical therapeutics. Taking advantage of emerging insight into structure/function relationships in...
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Full title
Identification of druggable small molecule antagonists of the Plasmodium falciparum hexose transporter PfHT and assessment of ligand access to the glucose permeation pathway via FLAG-mediated protein engineering
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TN_cdi_plos_journals_2222682666
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2222682666
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0216457
