Yin/Yang expression of CCN family members: Transforming growth factor beta 1, via ALK5/FAK/MEK, indu...
Yin/Yang expression of CCN family members: Transforming growth factor beta 1, via ALK5/FAK/MEK, induces CCN1 and CCN2, yet suppresses CCN3, expression in human dermal fibroblasts
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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The role of the microenvironment in driving connective tissue disease is being increasingly appreciated. Matricellular proteins of the CCN family are signaling modifiers that are secreted by cells into the extracellular matrix microenvironment where they have profound, context-dependent effects on organ development, homeostasis and disease. Indeed,...
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Full title
Yin/Yang expression of CCN family members: Transforming growth factor beta 1, via ALK5/FAK/MEK, induces CCN1 and CCN2, yet suppresses CCN3, expression in human dermal fibroblasts
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TN_cdi_plos_journals_2236168989
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2236168989
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0218178
