Revealing evolutionary constraints on proteins through sequence analysis
Revealing evolutionary constraints on proteins through sequence analysis
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United States: Public Library of Science
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English
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United States: Public Library of Science
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Contents
Statistical analysis of alignments of large numbers of protein sequences has revealed "sectors" of collectively coevolving amino acids in several protein families. Here, we show that selection acting on any functional property of a protein, represented by an additive trait, can give rise to such a sector. As an illustration of a selected trait, we...
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Full title
Revealing evolutionary constraints on proteins through sequence analysis
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TN_cdi_plos_journals_2250642943
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2250642943
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ISSN
1553-7358,1553-734X
E-ISSN
1553-7358
DOI
10.1371/journal.pcbi.1007010
