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The tumor suppressor BRCA1-BARD1 complex localizes to the synaptonemal complex and regulates recombi...

The tumor suppressor BRCA1-BARD1 complex localizes to the synaptonemal complex and regulates recombi...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2251023999

The tumor suppressor BRCA1-BARD1 complex localizes to the synaptonemal complex and regulates recombination under meiotic dysfunction in Caenorhabditis elegans

About this item

Full title

The tumor suppressor BRCA1-BARD1 complex localizes to the synaptonemal complex and regulates recombination under meiotic dysfunction in Caenorhabditis elegans

Publisher

United States: Public Library of Science

Journal title

PLoS genetics, 2018-11, Vol.14 (11), p.e1007701-e1007701

Language

English

Formats

Publication information

Publisher

United States: Public Library of Science

More information

Scope and Contents

Contents

Breast cancer susceptibility gene 1 (BRCA1) and binding partner BRCA1-associated RING domain protein 1 (BARD1) form an essential E3 ubiquitin ligase important for DNA damage repair and homologous recombination. The Caenorhabditis elegans orthologs, BRC-1 and BRD-1, also function in DNA damage repair, homologous recombination, as well as in meiosis....

Alternative Titles

Full title

The tumor suppressor BRCA1-BARD1 complex localizes to the synaptonemal complex and regulates recombination under meiotic dysfunction in Caenorhabditis elegans

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_plos_journals_2251023999

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2251023999

Other Identifiers

ISSN

1553-7404,1553-7390

E-ISSN

1553-7404

DOI

10.1371/journal.pgen.1007701

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