TDP-43 induces mitochondrial damage and activates the mitochondrial unfolded protein response
TDP-43 induces mitochondrial damage and activates the mitochondrial unfolded protein response
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United States: Public Library of Science
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English
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United States: Public Library of Science
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Mutations in or dys-regulation of the TDP-43 gene have been associated with TDP-43 proteinopathy, a spectrum of neurodegenerative diseases including Frontotemporal Lobar Degeneration (FTLD) and Amyotrophic Lateral Sclerosis (ALS). The underlying molecular and cellular defects, however, remain unclear. Here, we report a systematic study combining an...
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Full title
TDP-43 induces mitochondrial damage and activates the mitochondrial unfolded protein response
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TN_cdi_plos_journals_2251079466
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2251079466
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ISSN
1553-7404,1553-7390
E-ISSN
1553-7404
DOI
10.1371/journal.pgen.1007947
