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Reiterative Enrichment and Authentication of CRISPRi Targets (REACT) identifies the proteasome as a...

Reiterative Enrichment and Authentication of CRISPRi Targets (REACT) identifies the proteasome as a...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2251132622

Reiterative Enrichment and Authentication of CRISPRi Targets (REACT) identifies the proteasome as a key contributor to HIV-1 latency

About this item

Full title

Reiterative Enrichment and Authentication of CRISPRi Targets (REACT) identifies the proteasome as a key contributor to HIV-1 latency

Publisher

United States: Public Library of Science

Journal title

PLoS pathogens, 2019-01, Vol.15 (1), p.e1007498-e1007498

Language

English

Formats

Publication information

Publisher

United States: Public Library of Science

More information

Scope and Contents

Contents

The establishment of HIV-1 latency gives rise to persistent chronic infection that requires life-long treatment. To reverse latency for viral eradiation, the HIV-1 Tat protein and its associated ELL2-containing Super Elongation Complexes (ELL2-SECs) are essential to activate HIV-1 transcription. Despite efforts to identify effective latency-reversi...

Alternative Titles

Full title

Reiterative Enrichment and Authentication of CRISPRi Targets (REACT) identifies the proteasome as a key contributor to HIV-1 latency

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_plos_journals_2251132622

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2251132622

Other Identifiers

ISSN

1553-7374,1553-7366

E-ISSN

1553-7374

DOI

10.1371/journal.ppat.1007498

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