Biphasic and cardiomyocyte-specific IFIT activity protects cardiomyocytes from enteroviral infection
Biphasic and cardiomyocyte-specific IFIT activity protects cardiomyocytes from enteroviral infection
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United States: Public Library of Science
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English
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United States: Public Library of Science
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Viral myocarditis is a serious disease, commonly caused by type B coxsackieviruses (CVB). Here we show that innate immune protection against CVB3 myocarditis requires the IFIT (IFN-induced with tetratricopeptide) locus, which acts in a biphasic manner. Using IFIT locus knockout (IFITKO) cardiomyocytes we show that, in the absence of the IFIT locus,...
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Full title
Biphasic and cardiomyocyte-specific IFIT activity protects cardiomyocytes from enteroviral infection
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TN_cdi_plos_journals_2251139474
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2251139474
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ISSN
1553-7374,1553-7366
E-ISSN
1553-7374
DOI
10.1371/journal.ppat.1007674
