Locus suicide recombination actively occurs on the functionally rearranged IgH allele in B-cells fro...
Locus suicide recombination actively occurs on the functionally rearranged IgH allele in B-cells from inflamed human lymphoid tissues
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Author / Creator
Dalloul, Iman , Boyer, François , Dalloul, Zeinab , Pignarre, Amandine , Caron, Gersende , Fest, Thierry , Chatonnet, Fabrice , Delaloy, Céline , Durandy, Anne , Jeannet, Robin , Lereclus, Emilie , Boutouil, Hend , Aldigier, Jean-Claude , Péron, Sophie , Le Noir, Sandrine , Cook-Moreau, Jeanne and Cogné, Michel
Publisher
United States: Public Library of Science
Journal title
Language
English
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Publisher
United States: Public Library of Science
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Scope and Contents
Contents
B-cell activation yields abundant cell death in parallel to clonal amplification and remodeling of immunoglobulin (Ig) genes by activation-induced deaminase (AID). AID promotes affinity maturation of Ig variable regions and class switch recombination (CSR) in mature B lymphocytes. In the IgH locus, these processes are under control of the 3' regula...
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Full title
Locus suicide recombination actively occurs on the functionally rearranged IgH allele in B-cells from inflamed human lymphoid tissues
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Record Identifier
TN_cdi_plos_journals_2258818702
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2258818702
Other Identifiers
ISSN
1553-7404,1553-7390,1932-6203
E-ISSN
1553-7404,1932-6203
DOI
10.1371/journal.pgen.1007721
