Nilotinib interferes with cell cycle, ABC transporters and JAK-STAT signaling pathway in CD34+/lin-...
Nilotinib interferes with cell cycle, ABC transporters and JAK-STAT signaling pathway in CD34+/lin- cells of patients with chronic phase chronic myeloid leukemia after 12 months of treatment
About this item
Full title
Author / Creator
Trojani, Alessandra , Pungolino, Ester , Dal Molin, Alessandra , Lodola, Milena , Rossi, Giuseppe , D’Adda, Mariella , Perego, Alessandra , Elena, Chiara , Turrini, Mauro , Borin, Lorenza , Bucelli, Cristina , Malato, Simona , Carraro, Maria Cristina , Spina, Francesco , Latargia, Maria Luisa , Artale, Salvatore , Spedini, Pierangelo , Anghilieri, Michela , Di Camillo, Barbara , Baruzzo, Giacomo , De Canal, Gabriella , Iurlo, Alessandra , Morra, Enrica and Cairoli, Roberto
Publisher
United States: Public Library of Science
Journal title
Language
English
Formats
Publication information
Publisher
United States: Public Library of Science
Subjects
More information
Scope and Contents
Contents
Chronic myeloid leukemia (CML) is characterized by the constitutive tyrosine kinase activity of the oncoprotein BCR-ABL1 in myeloid progenitor cells that activates multiple signal transduction pathways leading to the leukemic phenotype. The tyrosine-kinase inhibitor (TKI) nilotinib inhibits the tyrosine kinase activity of BCR-ABL1 in CML patients....
Alternative Titles
Full title
Nilotinib interferes with cell cycle, ABC transporters and JAK-STAT signaling pathway in CD34+/lin- cells of patients with chronic phase chronic myeloid leukemia after 12 months of treatment
Authors, Artists and Contributors
Author / Creator
Pungolino, Ester
Dal Molin, Alessandra
Lodola, Milena
Rossi, Giuseppe
D’Adda, Mariella
Perego, Alessandra
Elena, Chiara
Turrini, Mauro
Borin, Lorenza
Bucelli, Cristina
Malato, Simona
Carraro, Maria Cristina
Spina, Francesco
Latargia, Maria Luisa
Artale, Salvatore
Spedini, Pierangelo
Anghilieri, Michela
Di Camillo, Barbara
Baruzzo, Giacomo
De Canal, Gabriella
Iurlo, Alessandra
Morra, Enrica
Cairoli, Roberto
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_plos_journals_2260251564
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2260251564
Other Identifiers
ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0218444
