Attenuation of chronic antiviral T-cell responses through constitutive COX2-dependent prostanoid syn...
Attenuation of chronic antiviral T-cell responses through constitutive COX2-dependent prostanoid synthesis by lymph node fibroblasts
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
Lymphoid T-zone fibroblastic reticular cells (FRCs) actively promote T-cell trafficking, homeostasis, and expansion but can also attenuate excessive T-cell responses via inducible nitric oxide (NO) and constitutive prostanoid release. It remains unclear how these FRC-derived mediators dampen T-cell responses and whether this occurs in vivo. Here, w...
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Full title
Attenuation of chronic antiviral T-cell responses through constitutive COX2-dependent prostanoid synthesis by lymph node fibroblasts
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TN_cdi_plos_journals_2276053470
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2276053470
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ISSN
1545-7885,1544-9173
E-ISSN
1545-7885
DOI
10.1371/journal.pbio.3000072
