MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants...
MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition
About this item
Full title
Author / Creator
Vande Walle, Lieselotte , Stowe, Irma B. , Šácha, Pavel , Lee, Bettina L. , Demon, Dieter , Fossoul, Amelie , Van Hauwermeiren, Filip , Saavedra, Pedro H. V. , Šimon, Petr , Šubrt, Vladimír , Kostka, Libor , Stivala, Craig E. , Pham, Victoria C. , Staben, Steven T. , Yamazoe, Sayumi , Konvalinka, Jan , Kayagaki, Nobuhiko and Lamkanfi, Mohamed
Publisher
United States: Public Library of Science
Journal title
Language
English
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Publication information
Publisher
United States: Public Library of Science
Subjects
More information
Scope and Contents
Contents
The nucleotide-binding-domain (NBD)-and leucine-rich repeat (LRR)-containing (NLR) family, pyrin-domain-containing 3 (NLRP3) inflammasome drives pathological inflammation in a suite of autoimmune, metabolic, malignant, and neurodegenerative diseases. Additionally, NLRP3 gain-of-function point mutations cause systemic periodic fever syndromes that a...
Alternative Titles
Full title
MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition
Authors, Artists and Contributors
Author / Creator
Stowe, Irma B.
Šácha, Pavel
Lee, Bettina L.
Demon, Dieter
Fossoul, Amelie
Van Hauwermeiren, Filip
Saavedra, Pedro H. V.
Šimon, Petr
Šubrt, Vladimír
Kostka, Libor
Stivala, Craig E.
Pham, Victoria C.
Staben, Steven T.
Yamazoe, Sayumi
Konvalinka, Jan
Kayagaki, Nobuhiko
Lamkanfi, Mohamed
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_plos_journals_2306255855
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2306255855
Other Identifiers
ISSN
1545-7885,1544-9173
E-ISSN
1545-7885
DOI
10.1371/journal.pbio.3000354
