Fanconi-BRCA pathway mutations in childhood T-cell acute lymphoblastic leukemia
Fanconi-BRCA pathway mutations in childhood T-cell acute lymphoblastic leukemia
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Author / Creator
Pouliot, Gayle P. , Degar, James , Hinze, Laura , Kochupurakkal, Bose , Vo, Chau D. , Burns, Melissa A. , Moreau, Lisa , Ganesa, Chirag , Roderick, Justine , Peirs, Sofie , Menten, Bjorn , Loh, Mignon L. , Hunger, Stephen P. , Silverman, Lewis B. , Harris, Marian H. , Stevenson, Kristen E. , Weinstock, David M. , Weng, Andrew P. , Van Vlierberghe, Pieter , D’Andrea, Alan D. and Gutierrez, Alejandro
Publisher
United States: Public Library of Science
Journal title
Language
English
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Publication information
Publisher
United States: Public Library of Science
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More information
Scope and Contents
Contents
BRCA2 (also known as FANCD1) is a core component of the Fanconi pathway and suppresses transformation of immature T-cells in mice. However, the contribution of Fanconi-BRCA pathway deficiency to human T-cell acute lymphoblastic leukemia (T-ALL) remains undefined. We identified point mutations in 9 (23%) of 40 human T-ALL cases analyzed, with varian...
Alternative Titles
Full title
Fanconi-BRCA pathway mutations in childhood T-cell acute lymphoblastic leukemia
Authors, Artists and Contributors
Author / Creator
Degar, James
Hinze, Laura
Kochupurakkal, Bose
Vo, Chau D.
Burns, Melissa A.
Moreau, Lisa
Ganesa, Chirag
Roderick, Justine
Peirs, Sofie
Menten, Bjorn
Loh, Mignon L.
Hunger, Stephen P.
Silverman, Lewis B.
Harris, Marian H.
Stevenson, Kristen E.
Weinstock, David M.
Weng, Andrew P.
Van Vlierberghe, Pieter
D’Andrea, Alan D.
Gutierrez, Alejandro
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_plos_journals_2314305723
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2314305723
Other Identifiers
ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0221288
