Induction of PGRN by influenza virus inhibits the antiviral immune responses through downregulation...
Induction of PGRN by influenza virus inhibits the antiviral immune responses through downregulation of type I interferons signaling
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Author / Creator
Wei, Fanhua , Jiang, Zhimin , Sun, Honglei , Pu, Juan , Sun, Yipeng , Wang, Mingyang , Tong, Qi , Bi, Yuhai , Ma, Xiaojing , Gao, George Fu and Liu, Jinhua
Publisher
United States: Public Library of Science
Journal title
Language
English
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Publication information
Publisher
United States: Public Library of Science
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Scope and Contents
Contents
Type I interferons (IFNs) play a critical role in host defense against influenza virus infection, and the mechanism of influenza virus to evade type I IFNs responses remains to be fully understood. Here, we found that progranulin (PGRN) was significantly increased both in vitro and in vivo during influenza virus infection. Using a PGRN knockdown as...
Alternative Titles
Full title
Induction of PGRN by influenza virus inhibits the antiviral immune responses through downregulation of type I interferons signaling
Authors, Artists and Contributors
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Record Identifier
TN_cdi_plos_journals_2314933908
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2314933908
Other Identifiers
ISSN
1553-7374,1553-7366
E-ISSN
1553-7374
DOI
10.1371/journal.ppat.1008062
